Scientific publications
Ghislain Donald Njambe Priso
Other affiliations: Centre International De Reference Chantal Biya
Abel Lissom
Other affiliations: Centre International De Reference Chantal Biya
Loveline Ngu
Other affiliations: Centre International De Reference Chantal Biya
Jules Colince Tchadji
Other affiliations: Centre International De Reference Chantal Biya
Thibau Flaurant Tchouangueu
Other affiliations: Université de Dschang · Centre International De Reference Chantal Biya
Georgia Ambada
Other affiliations: Centre International De Reference Chantal Biya
Carole Stéphanie Sake
Other affiliations: Centre International De Reference Chantal Biya
Brigitte Laure Dafeu
Other affiliations: Centre International De Reference Chantal Biya
Larissa Djukouo
Other affiliations: Centre International De Reference Chantal Biya
Inès Nyebe
Other affiliations: Centre International De Reference Chantal Biya
Suzanne H. Magagoum
Other affiliations: Centre International De Reference Chantal Biya
Nadesh Nji
Godwin Nchinda* (Corresponding author)
Other affiliations: Yaoundé Gynaecology, Obstetrics and Pediatrics Hospital
Apeh A. Ngoh
Other affiliations: Centre International De Reference Chantal Biya
Ouambo Fotso Herve
Other affiliations: Centre International De Reference Chantal Biya
Arinze S. Okoli
Charles Okechukwu Esimone
Chae Gyu Park
Alain Bopda Waffo
Other affiliations: Alabama State University
Rosario García
Anna Gutiérrez
BMC Infectious Diseases
BACKGROUND: In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis. METHODS: In this study we have assessed in plasma from asymptomatic anti-retroviral (ARV) naïve Loa loa microfilaraemic HIV-1 infected people the filarial antibody responses specific to a filariasis composite antigen consisting of Wbgp29-BmR1-BmM14-WbSXP. The antibody responses specific to the filariasis composite antigen was determined by enzyme linked immunosorbent assay (ELISA) in plasma from ARV naïve Loa loa microfilaraemic HIV-1 infected participants. In addition the filarial antigen specific IgG antibody subclass profiles were also determined for both HIV-1 positive and negative people. RESULTS: Both Loa loa microfilaraemic HIV-1 positive and negative individuals showed significantly higher plasma levels of IgG1 (P < 0.0001), IgG2 (P < 0.0001) and IgM (P < 0.0001) relative to amicrofilaraemic participants. A significant increase in IgE (P < 0.0001) was observed exclusively in Loa loa microfilaraemic HIV-1 infected people. In contrast there was a significant reduction in the level of IgG4 (p < 0.0001) and IgG3 (P < 0.0001) in Loa loa microfilaraemic HIV-1 infected individuals. CONCLUSIONS: Loa loa microfilaraemia in ARV naïve HIV-1 infected people through differential reduction of plasma levels of filarial antigen specific IgG3, IgG4 and a significant increase in plasma levels of filarial antigen specific IgE could diminish Loa loa mediated immune-regulation. This in effect can result to increase loaisis mediated immunopathology in antiretroviral naive HIV-1 infected people.
