Scientific publications
2017Journal articleEnglish
A Nitrile Glucoside and Biflavones from the Leaves of Campylospermum excavatum (Ochnaceae) (opens in a new tab)
Authors
University of Yaoundé I
Gaétan Bayiha Ba Njock
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Scientific publications
Gaétan Bayiha Ba Njock
Raphaë͏l Grougnet* (Corresponding author)
Other affiliations: Université Paris Cité · Sorbonne Paris Cité · Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
Sylvie Michel
Other affiliations: Université Paris Cité · Sorbonne Paris Cité · Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
Marina Kritsanida* (Corresponding author)
Other affiliations: Université Paris Cité · Sorbonne Paris Cité · Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
Antonia Efstathiou
Despina Smirlis
Grégory Genta‐Jouve
Other affiliations: Centre National de la Recherche Scientifique · Université Paris Cité · Sorbonne Paris Cité · Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
Chemistry & Biodiversity
The study of the MeOH extract of the leaves of Campylospermum excavatum led to the isolation of a nitrile glucoside, named campyloside C (1) and an original derivative of ochnaflavone, 7-O-methylochnaflavone (2), along with three known biflavonoids, amentoflavone, sequoiaflavone, and sotetsuflavone (3 - 5). The linkage site of the sub-units of 2 was confirmed by chemical correlation, after semi-synthesis of a trimethoxylated derivative of ochnaflavone (2a). The structures of these compounds as well as their relative and absolute configurations were assigned by 1D- and 2D-NMR experiments, HR-ESI-MS and Electronic Circular Dichroism (ECD) calculations. A low-pass J filter HMBC experiment was performed in order to define the configuration of the double bond of 1. All of the biflavonoids were evaluated against protozoan parasites. Amentoflavone moderately inhibited the promastigote form of Leishmania infantum.