Scientific publications
2009Journal articleSpanish
Antimicrobial Dihydroisocoumarins from Crassocephalum biafrae (opens in a new tab)
Authors
University of Yaoundé I
Gislain Fotso
Joseph Ngoupayo
Bonaventure T. Ngadjui
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Scientific publications
Gislain Fotso
Joseph Ngoupayo
Bonaventure T. Ngadjui
Anne‐Claire Mitaine‐Offer
Marie‐Aleth Lacaille‐Dubois
Planta Medica
Bioassay-guided fractionation of the CHCl (3)-soluble extract of the stem bark of Crassocephalum biafrae (Asteraceae) resulted in the isolation of three new dihydroisocoumarins, named biafraecoumarins A ( 1), B ( 2), and C ( 3); two known triterpenes ( 4 and 5); and a known ceramide ( 6). The structures of the new compounds were established as 7-but-15-enyl-6,8-dihydroxy-3( R)-penta-9,11-dienylisochroman-1-one ( 1), 7-butyl-6,8-dihydroxy-3( R)-penta-9,11-dienylisochroman-1-one ( 2), and 7-butyl-6,8-dihydroxy-3( R)-pent-10-enylisochroman-1-one ( 3) using spectroscopic data. Compounds 1- 3 exhibit low to significant antimicrobial activities against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Pseudomonas picketti, Trichphyton longifusus, Aspergillus flavus, Microsporum canis, Fusarium solani, Candida albicans, and Candida glabrata.