Scientific publications
Fongang Fotsing Yannick Stéphane* (Corresponding author)
Other affiliations: University of Karachi · University of Maroua · International Center for Chemical and Biological Sciences
Awantu Angelbert Fusi
Other affiliations: University of Bamenda
Kagho Kenou Donald Ulrich
Lenta Ndjakou Bruno
Amadou Dawé
Bankeu Kezetas Jean Jules* (Corresponding author)
Mehreen Lateef
Muhammad Shaiq Ali
Other affiliations: International Center for Chemical and Biological Sciences
Natural Product Research
The phytochemical investigation of the methanol extract of the bark of Croton oligandrus Pierre ex Hutch yielded a new clerodane-type diterpenoid crotoliganfuran (1) along with ten other compounds including 12-epicrotocorylifuran (2), lupeol (3), syringic acid (4), aleuritolic acid acetate (5), aleuritolic acid (6), scopoletin (7), geddic acid (8), β-sitosterol (9), vanilic acid (10) and stigmastane-3,6-dione (11). Their structures were established by spectroscopic means. The extract and all the isolates were screened for their inhibitory properties against butyrylcholinesterase and urease enzymes, respectively. The extract and compounds 1, 4 and 7 displayed the most potent urease inhibitory properties with IC50 values, 22.2, 26.7 and 28.5 µM, respectively. Compound 9 was the most active of all the tested compounds against butyrylcholinesterase enzyme with an IC50 value of 36.3 µM.
