Scientific publications
Godloves Fru
Elisabeth Zeuko’o Menkem
Ngadjui Bonaventure Tchaleu
Ache Roland Ndifor* (Corresponding author)
Njinga Ngaitad Stanislaus
Ferdinand Mouafo Talontsi
Yeboah Samuel Owusu
Biochemistry and Biophysics Reports
Synsepalum msolo commonly known as Bang Bali in Bali-Nguemba, Cameroon is used in traditional medicine against various diseases. The leaves and stem bark extracts were subjected to silica gel and Sephadex LH20 column chromatography to yield pure compounds. The structures of the compounds were determined by detail analysis of NMR and Mass spectroscopic data and by comparison with data reported in the literature. Amongst the isolates, were two new sphingolipids: synsepaloside B (1), synsepaloside C (2), and five known compounds: (+)-catechin (3), (−)-epicatechin (4), myricitrin (5), triacontanol (6), and aurantiamide acetate (7). Compounds 1–5 were screened for their antibacterial and anti-yeast activities on several microorganisms. All the tested compounds exhibited weak antibacterial (MIC ≥ 200 μg/mL) and anti-yeast (MIC > 200 μg/mL) activities as compared to standard: ciprofloxacin 0.468 < MIC >0.234 μg/mL and fluconazole MIC = 0.05 μg/mL, respectively.
