Scientific publications
Marlise Diane Jiofack Dongfack
Other affiliations: Délégation Paris 5 · Centre National de la Recherche Scientifique · Université Paris Cité · Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
Céline Djama Mbazoa
Marie‐Christine Lallemand
Other affiliations: Centre National de la Recherche Scientifique · Université Paris Cité · Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
Hanh Trinh‐Van‐Dufat
Other affiliations: Centre National de la Recherche Scientifique · Université Paris Cité · Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
Sylvie Michel
Other affiliations: Centre National de la Recherche Scientifique · Université Paris Cité · Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale
Victor Kuete
Jean‐Duplex Wansi
Chemical and Pharmaceutical Bulletin
From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2',3'-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(-) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1-3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 µg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 µg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii.
